Health Across Organ Systems
Supporting Sexual Health and Hormonal Balance
Declining sex hormone levels are associated with increased risk for disease and age-related decline in both men and women. For example, decreased levels of testosterone and estrogen have been associated with increased risk for cardiovascular disease (1) and dementia (2), and contribute to the loss of muscle and bone mass that frequently affects independence in old age (1). Lowered testosterone levels are also associated with risk for metabolic dysfunction and diabetes in men (3).
Preclinical studies suggest that low levels of vitamin B6 can lead to low testosterone (4), and that supplementing vitamin B6 supports testosterone production (5). A study of men receiving treatment for infertility found correlations between B12 levels in the blood and testosterone measurements (6). Other studies have suggested that vitamin B12 is important for pathways that support sperm health (7)
Low NAD+ and high Homocysteine levels are associated with Sexual Function
Elevated homocysteine and lowered testosterone levels are common in men with erectile dysfunction (8). In addition, preclinical studies suggest that boosting NAD+ levels in aged animals and in young animals with niacin deficiency leads to improvements in testicular tissue (9) and function (10).
Nicotinamide supports healthy blood vessel function and blood pressure regulation (11). In combination with our blend of B vitamins, which is formulated to reduce homocysteine and support testosterone production, Youth & Vitality supports sexual function.
Bone and Muscle Health
Aging is associated with loss of muscle mass and deterioration of bone structure; addressing these changes is important to maintaining healthy body function, independence, and healthspan.
Low NAD+ levels are associated with poorer muscle function, including muscle mitochondrial health, especially in individuals that are not physically active (12). Preclinical studies have suggested that in addition to supporting muscle function, NAD+ and vitamin B6 supplementation may stimulate muscle stem cells to slow or even reverse aging-associated muscle loss (13).
In addition, high homocysteine has been associated with decreased bone mineral density, which increases the risk of bone fractures, especially with age (14). Decreasing homocysteine may support bone health, working synergistically to promote strength and body function.
Read the Research
1. Male sex hormones, aging, and inflammation
2. Influence of the Onset of Menopause on the Risk of Developing Alzheimer’s Disease
3. Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis
4. Increased target tissue uptake of, and sensitivity to, testosterone in the vitamin B6 deficient rat
5. Role of Vitamin B6 in Testosterone Synthesis
7. Vitamin B12 and Semen Quality
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10. Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice
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12. Healthy aging and muscle function are positively associated with NAD+ abundance in humans