NAD+ Levels Decrease With Age
Our cells are constantly producing, using, and recycling NAD+ in order to function. However, as we age our overall NAD+ levels decline. By the time we're in our 50s, our NAD+ levels can be less than half of what they were as young adults. As NAD+ levels drop with age, our cells and their mitochondria become less efficient, and many pathways, including inflammatory and cellular repair pathways, become dysregulated. This decline is believed to be a key contributor to age-related issues like fatigue, cognitive decline, and increased susceptibility to disease, especially metabolic and neurodegenerative disorders.
By boosting NAD+ levels, supplements can improve cellular health and renewal, restore mitochondrial function, and enhance energy production, all of which can support potentially slowing down or even reversing some aspects of aging.
NAD+ is a large molecule and is poorly absorbed by the gut. Nicotinamide is an NAD+ precursor, a molecule that the body can easily convert into NAD+, and is absorbed much more efficiently from oral supplements.
Nicotinamide Effectively Supplements NAD+ Levels
NAD+ Supplements Support Metabolic Health
Evidence from human clinical trials as well as research done in animals suggests that NAD+ supplementation may improve insulin sensitivity in aging populations. A study in overweight, prediabetic postmenopausal women found that NMN supplementation improved muscle insulin sensitivity and absorption of sugar from the blood, which are critical for lowering the risk of type 2 diabetes.